Whole Foods, Healthy Fats, and the Hydrophobic-Hydrophilic Balance: A Strategy to Alleviate Inflammation and Insulin Resistance

The terms “hydrophobic” and “hydrophilic” may sound like jargon reserved for scientists, but they have real-world implications for everyday health, especially when it comes to understanding inflammation and insulin resistance. These properties affect how nutrients like fatty acids and carbohydrates interact with water and, consequently, how they are metabolized in the body. Knowing this can give us actionable insights into selecting whole foods and healthy fats that can alleviate these metabolic challenges.
The Hydrophobic-Hydrophilic Balancing Act
Let’s start by revisiting the basics: fatty acids are hydrophobic, meaning they repel water, and carbohydrates like glucose are hydrophilic, meaning they attract water. These inherent properties dictate their behavior in our bodies, influencing not just how they are stored but also how they affect our metabolism and, by extension, inflammation and insulin sensitivity.
The Problem with Imbalance: Inflammation and Insulin Resistance
Insulin resistance and inflammation often go hand in hand. One reason is that the typical Western diet is high in processed foods, which usually contain unhealthy fats and simple sugars. These components can disrupt our hydrophobic-hydrophilic balance. Excess sugar in the bloodstream can attract more water, potentially causing issues like high blood pressure, while excess fatty acids can contribute to plaque formation in the arteries.
Both scenarios can contribute to systemic inflammation, perpetuating a cycle that exacerbates insulin resistance. In essence, the imbalance of these water-repelling and water-attracting nutrients in the body can create an environment ripe for metabolic issues.
The Power of Whole Foods
Whole foods, naturally rich in complex carbohydrates and healthy fats, can help restore this balance. Foods like fruits, vegetables, and whole grains are sources of complex carbohydrates that are rich in soluble fiber. This type of fiber, similar to soluble polysaccharides like pectin and beta-glucans, forms a gel-like substance in the gut, which can help regulate blood sugar levels and reduce inflammation.
Healthy Fats: Not All Fats are Created Equal
When we talk about fats, it’s essential to distinguish between unhealthy trans fats or excessive saturated fats and healthier options like monounsaturated and polyunsaturated fats found in olive oil, nuts, and fatty fish. Unlike the unhealthy fats that can contribute to inflammation and other metabolic issues, these healthy fats can actually improve insulin sensitivity and reduce inflammation.
The Combined Effect: Alleviating Inflammation and Insulin Resistance
The choice of better carbohydrates in the form of whole foods and healthier fats creates a synergistic effect. The soluble fiber from complex carbohydrates can slow down glucose absorption, reducing spikes in blood sugar and insulin levels. At the same time, healthy fats can improve cell membrane function, making cells more responsive to insulin. This dual action can significantly reduce inflammation and improve insulin sensitivity, helping to break the vicious cycle of metabolic dysfunction.
Final Thoughts
We often overlook the hydrophobic and hydrophilic properties of nutrients, but understanding these can offer valuable insights into managing metabolic health. By opting for whole foods and healthy fats, we can restore the body’s natural hydrophobic-hydrophilic balance, mitigating the underlying factors that contribute to inflammation and insulin resistance. In doing so, we move beyond merely managing symptoms, instead targeting the root causes of these increasingly common health issues.
For You: The Scope and Purpose of these articles
The science of milk production is a rich and evolving field. The goal of this article series is to distill research and clinical practice into doable steps that can help mothers struggling with low milk supply. The aim here is simplicity, clarity and utility.
It is indeed important to keep in mind the fact that each of us is our own individual biological system, with specific needs and unique responses to foods, herbs, and lifestyle changes. Use the information presented here to experiment safely and discover what works for you. If you are on any medication or have a diagnosed condition, be sure to coordinate with your healthcare provider about your proposed changes.
Research into milk supply problems is ongoing. As it advances, we’ll gain more complete knowledge. Until then, we can rely on traditional wisdom and emerging evidence to guide our choices.

Hi! I'm Hilary Jacobson, and I've been helping moms with milk supply issues for over 30 years. My book, 'Mother Food,' was a game-changer when it first came out, and I'm still at itโresearching, writing, and teaching to make sure new moms get the support they need. Want to stay in the loop? Sign up to my newsletter for updates.ย

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